Parallel Rod Floor Neurological

This protocol is designed for researchers examining ethanol induced motor incoordination in mice but it should be applicable to other sedative hypnotic drugs and to testing cerebellar mutant mice or mice with engineered genetic defects.

Parallel rod floor neurological. The parallel rod floor test is a new model of ataxia in mice. The apparatus was used in conjunction with a special version of the any maze to assess ataxia and locomotor activity simultaneously. This protocol is designed for researchers examining ethanol. It allows the simultaneous measurement of ataxia and locomotor activity.

The parallel rod floor tests high throughput design makes it an extremely versatile and valuable screening and phenotyping tool. The parallel rod floor apparatus designed for assessing the effects of drugs brain damage and disease on motor coordination and fatigue is ideal for use with knockout and transgenic mice. The parallel rod floor tests high throughput design makes it an extremely versatile and valuable screening and phenotyping tool. This approach reveals short and long term progressive changes including compromised biphasic motor function up to 85.

The parallel rod floor test is a new model of ataxia in mice. Photograph of the testing chamber with floor d. Leversen js haga m sigmundsson h. Motor performance across the life span.

A transparent narrow tunnel was suspended 30 cm above the floor. We have used the thy1 yfp h transgenic mouse line and the parallel rod floor test to produce an unbiased and robust method for the evaluation of the multiple effects of a validated model of controlled cortical injury. The parallel rod floor test is a new model of ataxia in mice. The floor of the tunnel was composed of evenly spaced parallel rods similar to the original floor test.

Footslips were detected when a paw touched a metal plate below the parallel rod floor thereby completing a circuit that was registered by the system. The parallel rod floor test for ataxia kamens and crabbe 2007 was modified. From children to adults. Kamens hm crabbe jc.

A measure of ataxia in mice. The parallel rod floor apparatus. The parallel rod floor test. This protocol is designed for researchers examining ethanol.

The effects of ethanol on exploration in dba 2 and c57bl 6 mice. Pmc free article lister rg. It allows the simultaneous measurement of ataxia and locomotor activity. Parallel rod walkway test for ataxia.

The parallel rod floor apparatus designed for assessing the effects of drugs brain damage and disease on motor coordination and fatigue is ideal for use with knockout and transgenic mice.